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Related Subjects: |Inclusion Body Myositis |Inflammatory Myopathies |Polymyositis |Dermatomyositis
Feature | Polymyositis | Dermatomyositis | Inclusion Body Myositis |
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Sex | Females ≥ males | Females ≥ males | Males ≥ females |
Age | Usually adults | Any age | Usually after age 50 years |
Onset | Acute or insidious | Acute or insidious | Insidious |
Distribution of Weakness | Proximal ≥ distal | Proximal ≥ distal | Selective (see text) |
Course | Often rapid | Often rapid | Gradual |
Serum Creatine Kinase | Often very high | Often very high | Normal or mild increase (≤ 12-fold) |
EMG | Myopathic ± neurogenic | Myopathic ± neurogenic | Myopathic ± neurogenic |
Response to Treatment | Good | Good | Poor |
Skin Changes | No | Yes | No |
Increased Incidence of Cancer | No | Yes | No |
Biopsy | Intrafascicular inflammatory infiltrates with CD8+ T cells | Perifascicular and often perivascular inflammatory infiltrates, composed of B cells and CD4+ T cells | Endomysial inflammation with infiltrates of CD8+ T cells; intracellular inclusions, rimmed vacuoles |