Middle East Resp Syndrome (MERS) Coronavirus
🦠 Middle East Respiratory Syndrome (MERS-CoV):
Fever may be absent in infants, elderly, immunosuppressed, or those on antipyretics → maintain suspicion in at-risk cases.
ℹ️ About
- Viral respiratory illness caused by MERS coronavirus (MERS-CoV).
- First identified in Saudi Arabia (2012), later reported in the Middle East, Asia, Europe, USA.
- 🐪 Camels = natural reservoir; human-to-human spread in healthcare settings.
🧬 Aetiology
- Novel coronavirus strain causing severe lower respiratory disease.
- Incubation: 2–14 days (median ~5–6).
- Transmission: droplets, direct contact, contaminated surfaces.
🤒 Clinical Features
- Respiratory: Fever, cough, dyspnoea → pneumonia, ARDS.
- GI: Diarrhoea, nausea, vomiting, abdominal pain.
- Severe illness: ARDS, septic shock, multi-organ failure; worse with diabetes, CKD, immunosuppression.
- Atypical: Afebrile presentation in high-risk groups.
🧪 Investigations
- 🩸 Bloods: U&E (AKI risk), LFTs, FBC.
- 💨 ABG: Assess hypoxaemia/respiratory failure.
- 🧫 PCR: Nasopharyngeal, sputum, or BAL = diagnostic gold standard.
- 🩻 CXR/CT: Bilateral pneumonia, ARDS, ground-glass opacities.
🛡️ Prevention
- 🚫 Avoid raw camel milk/urine & undercooked camel meat.
- 🏥 Strict infection control: standard + contact + airborne precautions.
- 😷 PPE: N95 mask, gown, gloves, eye protection for healthcare workers.
- 🚪 Isolation: suspected/confirmed patients in negative-pressure rooms if available.
💊 Management
- Supportive: ABCs, O₂, IV fluids, vasopressors if shock.
- Advanced: ITU/HDU for mechanical ventilation, renal replacement if needed.
- No licensed antivirals; investigational drugs under study.
- 🧴 Infection control = critical to prevent outbreaks (PPE, hand hygiene, surface disinfection).
- 🏠 Mild disease: home isolation until recovery.
📚 References