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Calcium Resonium
ℹ️ About
Always check the BNF link here for up-to-date guidance. 👩⚕️ This medicine is typically used under specialist or hospital supervision in the management of hyperkalaemia.
⚙️ Mode of Action
- Ion exchange resin → exchanges calcium ions (Ca²⁺) for potassium ions (K⁺) in the colon.
- Potassium is then eliminated in the faeces → lowers serum potassium levels.
💊 Indications & Dosing
- Hyperkalaemia (especially in severe oliguria, anuria, or dialysis patients).
- Oral: 15 g, 3–4 times daily.
- Rectal: 30 g PR, retain for ~9 hours, then irrigate. 💡 Useful when oral route is not feasible.
🔄 Interactions
- May reduce absorption of lithium 💊 and thyroxine 🦋.
- Separate administration times recommended.
⚠️ Cautions
- See BNF for full details.
- Monitor serum potassium, calcium, and magnesium closely.
- Use with caution in patients at risk of constipation or bowel obstruction.
⛔ Contraindications
- Serum potassium < 5 mmol/L.
- Pre-existing hypercalcaemia (e.g. hyperparathyroidism, multiple myeloma, sarcoidosis, metastatic cancer).
- History of hypersensitivity to polystyrene sulfonate resins.
- Obstructive bowel disease 🚫.
💥 Side Effects
- GI: Anorexia, constipation (⚠️ usually combine with laxative).
- Metabolic: Hypomagnesaemia, hypercalcaemia.
- Rare: Intestinal necrosis (especially with concomitant sorbitol).
📚 References
- BNF: Calcium Polystyrene Sulfonate
- Local hyperkalaemia management protocols (hospital guidelines).
📝 Revisions
- Last updated: September 2025
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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