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Bendroflumethiazide (Bendrofluazide) 💊
Always check the BNF here for up-to-date prescribing advice.
- ✔️ Refer to BNF or equivalent for safe, current dosing and contraindications.
⚙️ Mode of Action
- Thiazides block sodium reabsorption in the proximal segment of the distal convoluted tubule (DCT).
- Increased sodium is delivered to the distal nephron.
- The aldosterone-sensitive Na⁺/K⁺ exchange pump then causes ⬆️ potassium and hydrogen ion excretion.
📋 Indications & Standard Doses
- Hypertension: Bendroflumethiazide 2.5 mg OD
- Oedema: Bendroflumethiazide 5–10 mg OD
📏 Dose Range (check BNF/datasheet)
| Name | Dose | Frequency | Route |
|---|---|---|---|
| Bendroflumethiazide (HTN) | 2.5–5 mg | OD | PO |
| Bendroflumethiazide (Oedema) | 2.5–10 mg | OD or alternate days | PO |
🔄 Interactions
- Often used with ACE inhibitors/ARBs to reduce hypokalaemia risk.
- May enhance lithium toxicity (reduced clearance).
- NSAIDs may blunt antihypertensive effect.
⚠️ Cautions
- Diabetes mellitus (may ↑ glucose).
- Gout (may ↑ uric acid, precipitate flares).
- Nephrotic syndrome.
- Systemic lupus erythematosus (SLE).
⛔ Contraindications
- Severe renal impairment (check BNF for details).
- Refractory hypokalaemia or hyponatraemia.
- Hypersensitivity to thiazides.
⚡ Side Effects
- Metabolic: ⬆️ calcium, glucose, urate; ⬇️ chloride, bicarbonate, potassium, magnesium, sodium.
- Acute gout.
- Blood disorders: ↓ WCC, granulocytes, platelets.
- Skin: Rashes, photosensitivity.
- Hepatic: Cholestatic jaundice.
- Pulmonary: Rare pneumonitis.
📚 References
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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