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Galantamine
About: Always check the BNF link here
- NICE guidelines for usage and consult local guidelines
- Liaise with Geriatricians/Psychogeriatricians/Neurologists
- Side effects are significant so use should be carefully considered
Mode of action
- Acetylcholinesterase inhibitor
- Increases Neuronal Acetyl choline levels
- Effects on Muscarinic and Nicotinic receptors
Indications
- Clinical trials suggest that cholinesterase inhibitors may provide limited benefits for people with mild to moderately severe Alzheimer's disease and for people with dementia with Lewy bodies, vascular dementia or mixed dementia.
- Alzheimer's disease - mild to moderate
Interactions
- Metabolised by Cytochrome p450
Dose
- Galantamine 8, 16 and 24mg prolonged-release capsules.
Contraindications
- Sick sinus syndrome, Conduction defects, Asthma
- Cautions with Extrapyramidal disease and peptic ulcer disease
Side effects
- Cholinergic symptoms - diarrhoea, urination, miosis, bronchospasm
- Bradycardia, lacrimation, salivation
- Vomiting, muscle cramps, lowered blood pressure,
- Insomnia, fatigue and loss of appetite.
- Falls and dizziness. GI symptoms, Headache
References
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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