Makindo Medical Notes

B lymphocytes, or B cells, are a type of white blood cell that play a pivotal role in the adaptive immune response. They are primarily responsible for producing antibodies, presenting antigens, and forming immunological memory.

Development and Maturation of B Lymphocytes

• Origin:
  • B cells originate from hematopoietic stem cells in the bone marrow.
• B Cell Development:
  • Occurs in the bone marrow and involves several stages:
    • Pro-B cells: Initial stage with heavy chain gene rearrangement.
    • Pre-B cells: Characterized by light chain gene rearrangement and expression of the pre-B cell receptor.
    • Immature B cells: Express a complete B cell receptor (BCR) on their surface.
  • Negative selection removes self-reactive B cells to prevent autoimmunity.
• Mature B Cells:
  • Naïve B cells that have not yet encountered their specific antigen circulate in the blood and lymphoid organs.

B Cell Activation

• B cell activation occurs in response to antigen binding to the B cell receptor (BCR):
  • T Cell-Dependent Activation:
    • Requires help from helper T cells (CD4⁺ T cells).
    • Involves two signals:
      • Signal 1: Antigen binding to the BCR.
      • Signal 2: Interaction with helper T cells via CD40-CD40L and cytokines.
  • T Cell-Independent Activation:
    • Does not require T cell help.
    • Occurs through recognition of repetitive antigens, such as bacterial polysaccharides.
• Upon activation, B cells proliferate and differentiate into:
  • Plasma Cells: Produce and secrete large amounts of antibodies.
  • Memory B Cells: Provide long-term immunity by remembering past infections and responding more rapidly upon re-exposure to the same antigen.

Functions of B Lymphocytes

• Antibody Production:
  • Plasma cells, differentiated from B cells, secrete antibodies (immunoglobulins) specific to the antigen encountered.
  • Antibodies neutralize pathogens, opsonize bacteria for phagocytosis, and activate the complement system.
• Antigen Presentation:
  • B cells can present processed antigen to helper T cells via MHC class II molecules, facilitating T cell activation and cooperation.
• Immunological Memory:
  • Memory B cells persist in the body after an initial infection and mount a quicker and more robust response upon subsequent exposures to the same antigen.

Antibody Classes

• B cells produce different classes of antibodies (immunoglobulins), each with specific roles:
  • IgM: The first antibody produced in response to an infection; effective at activating complement.
  • IgG: The most abundant antibody in blood and extracellular fluid; provides long-term immunity and can cross the placenta.
  • IgA: Found in mucosal areas (e.g., gut, respiratory tract) and secretions (e.g., saliva, breast milk); protects mucosal surfaces.
  • IgE: Involved in allergic reactions and protection against parasitic infections.
  • IgD: Functions mainly as a B cell receptor on the surface of immature B cells.

Clinical Relevance

• Autoimmune Diseases:
  • Conditions where B cells produce autoantibodies that target the body's own tissues. Examples include systemic lupus erythematosus (SLE) and rheumatoid arthritis.
• Immunodeficiency:
  • Conditions where B cell function is impaired, leading to increased susceptibility to infections. Examples include X-linked agammaglobulinemia and common variable immunodeficiency (CVID).
• Vaccination:
  • Vaccines stimulate B cell responses, leading to the production of memory B cells and long-term immunity against specific pathogens.
• Monoclonal Antibodies:
  • Therapeutic antibodies produced by identical B cells that target specific antigens; used in the treatment of various diseases, including cancers and autoimmune disorders.

Summary

B lymphocytes are essential for the adaptive immune response, primarily through the production of antibodies, antigen presentation, and immunological memory. Understanding B cell development, activation, and function is crucial for diagnosing and treating immune-related diseases and developing effective vaccines and therapies.