Sodium Zirconium Cyclosilicate 💊

About: Always check the BNF link here for the most up-to-date prescribing advice.

• Non-absorbed cation-exchange compound that selectively binds potassium in the GI tract.
• Onset of action: about 1 hour ⏱️ (faster than patiromer).
• Always verify prescribing advice in the BNF or drug datasheet before use.

⚙️ Mode of Action

• Acts as a selective potassium binder in the gastrointestinal tract.
• Exchanges sodium and hydrogen ions for potassium, increasing faecal potassium excretion.

📌 Indication

• Treatment of hyperkalaemia.

💉 Dosing (check BNF for confirmation)

• Acute Hyperkalaemia: 10 g PO every 8 hours for up to 72 hours.
• Maintenance/Ongoing Hyperkalaemia: 5–10 g PO once daily.

🔄 Interactions

• Can reduce absorption of other oral medicines → give other drugs ≥ 2 hours before or after SZC.

⚠️ Cautions

• Fluid overload and oedema risk (due to sodium content).
• Patients with heart failure, hypertension, or CKD - monitor closely.

🚫 Contraindications

• Severe constipation, bowel obstruction, or impaction.
• History of hypersensitivity to the drug or excipients.

❗ Side Effects

• Fluid imbalance, oedema, peripheral swelling.
• Constipation, nausea.
• Hypokalaemia if excessive dosing.

📚 References

• BNF – Sodium Zirconium Cyclosilicate
• Renal and hyperkalaemia management guidelines.