Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Related Subjects: |OSCE Eye Exam |OSCE Ear Exam |OSCE Abdominal Exam |OSCE Ascites Exam |OSCE Jaundice Exam |OSCE Testicular Exam |OSCE Inguinal Exam |OSCE Upper limb Neurology |OSCE Lower limb Neurology |OSCE Face Neurology
Be ready to suggest possible diagnosis and investigations. One would want to measure bilirubin and liver function tests and FBC and consider an abdominal Ultrasound. In an older person with pronounced jaundice and well enough for an exam a gallstone in the common bile dict or Ca head of pancreas are likely. The later is usually painless. Management is an ERCP and removal of stones or stenting.
Cause Category | Cause | Mechanism/Pathophysiology | Key Clinical Features |
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Pre-hepatic | Haemolytic Anemia | Increased breakdown of red blood cells leading to elevated levels of unconjugated (indirect) bilirubin. | Anaemia, dark urine, splenomegaly, elevated lactate dehydrogenase (LDH), high reticulocyte count. |
Hepatic | Viral Hepatitis | Hepatocellular injury impairing bilirubin conjugation and excretion. | Jaundice, malaise, right upper quadrant pain, markedly elevated transaminases. |
Alcoholic Hepatitis | Alcohol-induced liver injury resulting in impaired bilirubin metabolism. | Jaundice, tender hepatomegaly, history of heavy alcohol use, elevated liver enzymes with AST:ALT ratio > 2. | |
Drug-induced Liver Injury | Hepatotoxicity from medications leading to hepatocellular damage and impaired bilirubin processing. | Jaundice, rash, fever, recent exposure to a hepatotoxic drug. | |
Gilbert’s Syndrome | Reduced activity of UDP-glucuronosyltransferase (UGT) causing mild unconjugated hyperbilirubinemia. | Mild, intermittent jaundice often precipitated by fasting, stress, or illness; typically asymptomatic otherwise. | |
Post-hepatic | Choledocholithiasis | Obstruction of the common bile duct by gallstones, leading to accumulation of conjugated (direct) bilirubin. | Jaundice, pale (acholic) stools, dark urine, pruritus, biliary colic. |
Pancreatic Cancer (Head of Pancreas) | Tumor in the pancreatic head compressing the common bile duct, causing obstructive jaundice. | Painless jaundice, weight loss, Courvoisier’s sign (palpable, non-tender gallbladder), steatorrhea. | |
Cholangiocarcinoma | Malignancy of the bile ducts resulting in bile flow obstruction. | Progressive jaundice, pruritus, pale stools, weight loss. |