Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Process | Enzyme | Regulators |
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Glycolysis | Phosphofructokinase-1 (PFK-1) |
AMP ⊕, fructose-2,6-bisphosphate ⊕
ATP ⊝, citrate ⊝ |
Gluconeogenesis | Fructose-1,6-bisphosphatase 1 | AMP ⊝, fructose-2,6-bisphosphate ⊝ |
TCA Cycle | Isocitrate dehydrogenase |
ADP ⊕
ATP ⊝, NADH ⊝ |
Glycogenesis | Glycogen Synthase |
Glucose-6-phosphate ⊕, insulin ⊕, cortisol ⊕
Epinephrine ⊝, glucagon ⊝ |
Glycogenolysis | Glycogen Phosphorylase |
Epinephrine ⊕, glucagon ⊕, AMP ⊕
Glucose-6-phosphate ⊝, insulin ⊝, ATP ⊝ |
HMP Shunt | Glucose-6-phosphate Dehydrogenase (G6PD) |
NADP+ ⊕
NADPH ⊝ |
De Novo Pyrimidine Synthesis | Carbamoyl Phosphate Synthetase II |
ATP ⊕, PRPP ⊕
UTP ⊝ |
De Novo Purine Synthesis | Glutamine-Phosphoribosylpyrophosphate (PRPP) Amidotransferase | AMP ⊝, Inosine Monophosphate (IMP) ⊝, GMP ⊝ |
Urea Cycle | Carbamoyl Phosphate Synthetase I | N-Acetylglutamate ⊕ |
Fatty Acid Synthesis | Acetyl-CoA Carboxylase (ACC) |
Insulin ⊕, citrate ⊕
Glucagon ⊝, palmitoyl-CoA ⊝ |
Fatty Acid Oxidation | Carnitine Acyltransferase I | Malonyl-CoA ⊝ |
Ketogenesis | HMG-CoA Synthase | |
Cholesterol Synthesis | HMG-CoA Reductase |
Insulin ⊕, thyroxine ⊕, estrogen ⊕
Glucagon ⊝, cholesterol ⊝ |