Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Related Subjects: |Ferritin |CEA |ESR |CRP |ALP |LDH |HbA1c |Alpha Fetoprotein |Neutrophil Alkaline Phosphatase |Anti-Hu ab |Anti-Yo ab |Anti-SCL70 ab |Prolactin |Liver Function Tests |Biochemical Lab values |Rheumatology Autoantibodies
Autoantibody | Disease |
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Rheumatoid factor (RF) | Antibodies directed at the Fc fragment of IgG and can be IgM, IgG or IgA. Routinely we look for IgM. They are found in 75% of RA disease. Found in 100% of RA with extraarticular manifestations. Seen in 5% of a normal population. These suggest more severe arthritis. Also seen in SLE, Sjogren's, Systemic sclerosis, Dermatomyositis. Cryoglobulinaemia, leprosy, bacterial endocarditis, hepatitis C, sarcoidosis, malignancy, chronic liver disease |
Anti-cyclic peptide (ACPA) | 70% of Rheumatoid arthritis. More specific than RF. Can be present for years before diagnosis. Suggest more severe disease. Can be seen in SLE and Sjogren's. Also autoimmune hepatitis type 1. |
Antinuclear antibodies | Non-specific – autoimmune disease, infections, normal individuals |
Anti-topoisomerase I (Scl-70) | Diffuse cutaneous SSc |
Anti Jo-1 | Polymyositis and Dermatomyositis |
Anti-centromeric | Limited SS |
Anti-RNA polymerase antibodies I and III | Systemic sclerosis |
Cytoplasmic ANCA | Granulomatosis with polyangiitis (Wegener’s granulomatosis) |
Perinuclear ANCA | Microscopic polyarteritis, eosinophilic granulomatosis with polyangiitis (formerly known as Churg–Strauss syndrome) |
IgG anti-dsDNA | SLE |
Anti-histone | Drug-induced lupus |
Anti-Ro (SS-A) | Primary SS, SLE |
Anti-La (SS-B) | Primary SS, SLE |
Beta2-glycoprotein 1 | Antiphospholipid syndrome |