Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Substance | Description | Clinical Significance | Common Use/Indication |
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Carboxyhaemoglobin | Form of hemoglobin bound to carbon monoxide (CO) | Indicates carbon monoxide poisoning | Monitoring and diagnosis of CO poisoning |
Digoxin | Cardiac glycoside used to treat heart conditions | Monitored to prevent toxicity due to narrow therapeutic index | Treatment of atrial fibrillation and heart failure |
Ethanol (in ethylene glycol and methanol poisoning) | Ethanol used as an antidote in ethylene glycol and methanol poisoning | Prevents toxic metabolite formation by inhibiting alcohol dehydrogenase | Treatment for ethylene glycol or methanol poisoning |
Ethylene and Diethylene Glycols | Highly toxic alcohols used in antifreeze and industrial solvents | Accidental or intentional ingestion leads to poisoning | Requires urgent treatment to prevent severe metabolic acidosis and renal failure |
Iron | Essential mineral, but toxic in high amounts | Excess iron can lead to oxidative damage and organ failure | Monitored in cases of iron overdose or hemochromatosis |
Lithium | Mood stabilizer used in psychiatric conditions | Requires close monitoring due to risk of toxicity | Used in the treatment of bipolar disorder |
Methanol | Toxic alcohol found in industrial solvents and antifreeze | Ingestion leads to metabolic acidosis and visual impairment | Requires antidote treatment with ethanol or fomepizole |
Paracetamol | Common pain reliever and fever reducer | Overdose can lead to liver failure | Monitored in cases of suspected overdose |
Salicylate | Component of aspirin (acetylsalicylic acid) | Overdose can lead to respiratory alkalosis and metabolic acidosis | Monitored in cases of aspirin overdose |
Poison | Antidote |
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Aluminium | Deferoxamine (Desferrioxamine) |
Arsenic | Dimercaprol (BAL), succimer (DMSA) |
Benzodiazepines | Flumazenil |
β-adrenoceptor-blocking drugs | Atropine, glucagon |
Calcium channel blockers | Atropine |
Carbamate insecticides | Atropine |
Carbon monoxide | Oxygen |
Copper | d-Penicillamine, unithiol (DMPS) |
Cyanide | Dicobalt edetate, hydroxocobalamin, oxygen, sodium nitrite, sodium thiosulfate |
Diethylene glycol | Fomepizole, ethanol |
Digoxin and digitoxin | Digoxin-specific antibody fragments |
Ethylene glycol | Fomepizole, ethanol |
Hydrogen sulphide | Oxygen |
Iron salts | Deferoxamine (Desferrioxamine) |
Lead (inorganic) | Succimer (DMSA), sodium calcium edetate |
Methaemoglobinaemia | Methylthioninium chloride (methylene blue) |
Methanol | Ethanol, fomepizole |
Mercury (inorganic) | Unithiol (DMPS) |
Nerve agents | Atropine, obidoxime, pralidoxime, HI-6 |
Oleander | Digoxin-specific antibody fragments |
Opioids | Naloxone |
Organophosphorus insecticides | Atropine, obidoxime, pralidoxime |
Paracetamol | Acetylcysteine |
Thallium | Prussian (Berlin) blue |
Warfarin and other anticoagulants | Phytomenadione (vitamin K1) |