Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Related Subjects: |Sideroblastic Anaemia |Splenectomy |Paroxysmal Nocturnal Haemoglobinuria |Pernicious anaemia |Normocytic anaemiaa |Pyruvate Kinase deficiency |Blood Products - Platelets |Von Willebrand Disease
PT result | APTT result | Common condition present | Prolonged | Normal | Liver disease, decreased Vitamin K, decreased or defective factor VII |
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Normal | Prolonged | Haemophilia A or B (decreased or defective factor VIII or IX) or factor XI deficiency, von Willebrand disease, factor XII deficiency, or lupus anticoagulant present |
Prolonged | Prolonged | Decreased or defective factor I (fibrinogen), II (prothrombin), V or X, severe liver disease, disseminated intravascular coagulation (DIC) |
Normal | Normal or slightly prolonged
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May indicate normal haemostasis; however, PT and PTT can be normal in conditions such as mild deficiencies in other factors and mild form of von Willebrand disease. Further testing may be required to diagnose these conditions. |