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SCL70 Antibody
Related Subjects: |Ferritin |CEA |ESR |CRP |ALP |LDH |HbA1c |Alpha Fetoprotein |Anti-Hu ab |Anti-Yo ab |Anti-SCL70 ab |Biochemical Lab values
🔎 About
- ⏳ Turnaround time for results may be several weeks.
🧬 Aetiology
- Progressive Systemic Sclerosis (PSS / systemic sclerosis) is a chronic systemic rheumatic disease affecting skin, GI tract, heart, lungs, and kidneys.
- 👩🦰 More common in females, usually onset between 20–50 years.
- Patients often have multiple autoantibodies (Scl-70, Sm, centromere, Ro, La, RNP).
- Anti-Scl-70 (Topoisomerase I) is found in ~15–20% of scleroderma cases, especially diffuse cutaneous systemic sclerosis (dcSSc, ~15–30%).
- 🔬 Difficult to detect by immunofluorescence (gives fine speckled nuclear pattern) - usually part of the ENA screen.
- 🌍 Occurs less frequently in Caucasians compared to some other ethnic groups.
- ⚠️ Presence does not correlate with disease activity but is associated with more aggressive systemic disease.
🩺 Clinical
- Seen in systemic sclerosis, particularly diffuse cutaneous disease.
- Often associated with:
- 🤲 Sclerodactyly (tight, thickened skin on hands).
- ❄️ Raynaud’s phenomenon.
- 🫁 Pulmonary fibrosis / interstitial lung disease.
- 🦴 Subcutaneous calcification.
- 🍽️ Oesophageal dysmotility.
- 🧠 Neurological symptoms (e.g., paraesthesia, brachial plexopathy, optic neuritis).
🧪 Investigations
- Anti-Scl-70 testing performed when the ENA screen is positive but Ro, La, RNP, Sm, and centromere are negative.
- Results usually reported as: ❌ Negative / ⚖️ Equivocal / ✅ Positive.
📚 References
- UpToDate: Systemic Sclerosis autoantibodies.
- BNF / NICE immunology guidance.
- 📖 Walker-Bone K. *Oxford Handbook of Rheumatology*.
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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