Renal Artery Stenosis |
- Resistant hypertension.
- Abdominal bruit.
- Sudden worsening of renal function.
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- Doppler ultrasound.
- CT/MR angiography.
- Renal function tests (e.g., serum creatinine).
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- Angioplasty with or without stenting.
- Antihypertensive therapy (ACE inhibitors/ARBs may be avoided in bilateral disease).
- Surgical revascularization.
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Primary Aldosteronism (Conn's Syndrome) |
- Hypertension with hypokalaemia.
- Muscle weakness, fatigue.
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- Serum aldosterone-to-renin ratio.
- Adrenal CT scan.
- 24-hour urinary aldosterone.
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- Adrenalectomy for unilateral disease.
- Mineralocorticoid receptor antagonists (e.g., Spironolactone).
- Potassium supplementation.
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Phaeochromocytoma |
- Paroxysmal hypertension.
- Headaches, palpitations, sweating.
- Orthostatic hypotension.
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- 24-hour urinary metanephrines and catecholamines.
- Plasma free metanephrines.
- Abdominal MRI/CT scan.
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- Surgical removal of tumour.
- Preoperative alpha-blockade (e.g., Phenoxybenzamine).
- Beta-blockers after alpha-blockade.
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Cushing's Syndrome |
- Central obesity, moon face.
- Buffalo hump, purple striae.
- Proximal muscle weakness.
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- 24-hour urinary free cortisol.
- Dexamethasone suppression test.
- Adrenal CT/MRI.
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- Surgical resection of the tumour.
- Medical therapy to control cortisol levels (e.g., Ketoconazole).
- Radiation therapy for pituitary tumours.
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Coarctation of the Aorta |
- Hypertension in upper limbs.
- Weak or absent femoral pulses.
- Delayed brachial-femoral pulse.
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- Chest X-ray (shows rib notching).
- Echocardiography.
- CT/MR angiography.
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- Surgical correction.
- Balloon angioplasty.
- Antihypertensive therapy.
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Thyroid Disease (Hyperthyroidism/Hypothyroidism) |
- Symptoms of hyperthyroidism (e.g., tachycardia, weight loss) or hypothyroidism (e.g., bradycardia, weight gain).
- Goitre or thyroid nodules.
- Heat or cold intolerance.
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- Thyroid function tests (TSH, T3, T4).
- Thyroid ultrasound.
- Radioactive iodine uptake test (for hyperthyroidism).
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- Thyroid hormone replacement (for hypothyroidism).
- Antithyroid drugs, radioactive iodine, or surgery (for hyperthyroidism).
- Beta-blockers (for symptomatic hyperthyroidism).
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Obstructive Sleep Apnoea (OSA) |
- Loud snoring.
- Daytime sleepiness.
- Observed apnoea's during sleep.
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- Polysomnography (sleep study).
- Home sleep apnoea testing.
- Oxygen saturation monitoring.
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- Continuous Positive Airway Pressure (CPAP) therapy.
- Weight loss.
- Surgical options (e.g., Uvulopalatopharyngoplasty [UPPP]).
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