Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Be very cautious with combinations of these drugs
Drugs | Details |
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Opiates/Codeine | Increased toxicity and sedation as well as constipation. Lower dose or avoid |
Benzodiazepines | Increased toxicity and sedation. Lower dose or avoid |
Diuretics | Can dehydrate and upset electrolytes - use cautiously. May worsen or precipitate AKI. |
Anticoagulants | Can precipitate bleeding |
Antiplatelets | Can precipitate bleeding |
NSAIDS | Can precipitate bleeding, fluid retention and AKI |
Steroids | Can precipitate infection and fluid retention |
Paracetamol | Risks of Toxicity |