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Creatinine Clearance
📑 Summary
⚠️ The Cockcroft–Gault formula assumes normal muscle mass. It may be inaccurate in muscle wasting, neuromuscular disease, or extremes of body habitus.
ℹ️ About
- 🧮 Widely used for >40 years to estimate renal function.
- ⚠️ Inaccurate with extremes of age, weight, or muscle mass.
- 💊 Creatinine clearance (CrCl) is often preferred over eGFR for drug dosing.
🧪 Physiology
- Creatinine = byproduct of muscle metabolism, cleared by kidneys.
- 🩸 Minimal reabsorption → a good marker of renal clearance.
- CrCl ≈ GFR (adjusted by age, sex, body size).
- Normal values in healthy young adults:
- 👩 Women ≈ 95 mL/min
- 👨 Men ≈ 120 mL/min
📊 Calculation
- Needs: 👤 Sex | 🎂 Age | ⚖️ Weight | 🧪 Serum creatinine (± Height for BSA).
- Formula:
CrCl (mL/min) = ((140 - Age) × Weight (kg) × [constant]) / Serum Creatinine (mg/dL)- Constant = 1.23 (men), 1.04 (women)
- ⚠️ Use with caution in elderly or those with abnormal muscle mass.
📚 References
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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